The Cytotoxic Properties and Anticancer Impacts of Zinc Oxide Nanoparticles on Human Breast, MCF7 Cell Lines

Ghasem Rahimi Kalateh Shah Mohammad 1*, Vahid Pouresmaeil 1


1 Biochemistry Department, Islamic Azad University, Mashhad Branch, Iran



Nanotechnology enable us to manipulate the substances at nanoscale level. Metallic nanomaterials such as Zn O nanoparticles synthesized with chemical methods, which has the disadvantage of using deleterious chemicals. Green chemistry allows the design and synthesis of nanoparticles, with reducing or elimination of hazardous materials. One of the important applications of zinc oxide nanoparticles is to use as an antibacterial and anticancer agent. In this study, we synthesized Zn O nanoparticle using Hyssopus officinalis plant extract and evaluate its their cytotoxicity on MCF7 breast cancer cell line.

Results showed that Zn O nanoparticles synthesized in Hyssopus officinalis plant extract are able to inhibit MCF7 cells. However, this inhibition was at low concentrations of Zn O nanoparticles and the values of IC50 (in 24, 48 and 72-hour treatment) respectively was calculated at 16, 10 and 5 μg/ml NPs.

Results of this study indicated the inhibitory effects of Zn O nanoparticles synthesized in Hyssopus officinalis plant extract on cancer cells. However, in vitro studies should perform in order to confirm these effects. Finally, these results demonstrate the anticancer potential of Zn O nanoparticles, which could be used as therapeutic agent in cancer therapy.

Keywords: Green Chemistry. Zn O Nanoparticles, Hyssopus Officinalis, MCF7 Cell Line, Breast Cancer

Doi: 10.28991/ICCR-2019-024


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